ACCELERATING. SYNTHETIC BIOLOGY. ADVANCEMENT

The Spanish textile group Inditex has announced its entry into the capital of Galy, a start-up or emerging company that has among its most important investors the CEO of OpenAI, Sam Altman, and which develops a cotton cultivation process in the laboratory to produce sustainable material.

Boston-based Galy, which uses technology similar to cell-based meat, is aiming to drastically reduce cotton’s environmental impact.

Black soldier flies could help cut planet-warming methane produced when organic waste breaks down, Macquarie University team says.

Black soldier flies which are currently commercially used to consume organic waste will now be able to tackle a wider variety of refuse thanks to genetic modifications devised by Macquarie University bioscientists.

The present invention relates to an apparel or shoe comprising an inner surface, wherein the inner surface comprises an area comprising spider silk.

The present invention is directed to a method of producing spider dragline and/or flagelliform proteins. The invention is further directed to a method of producing spider threads and to a dragline/flagelliform protein or dragline/flagelliform protein thread produced by these methods. The invention further provides the use of these proteins/threads in the field of biotechnology and/or medicine, in particular in the manufacture of wound closure or coverage systems, suture materials and in the manufacture of replacement materials, preferably artificial cartilage or tendon materials.

The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution.

The present invention is directed to recombinant spider silk proteins, nucleic acids, coding for these recombinant spider silk proteins, as well as hosts suitable for expressing those nucleic acids. Furthermore, the present invention is directed to a method of aggregation of spider silk proteins and the use of the proteins in the field of biotechnology and/or medicine and other industrial fields, in particular in the manufacture of automotive parts, in the aircraft construction, in the processing of textiles and leather, as well as in the manufacture and processing of paper and the like.

The results in the experimentation demonstrate that transgenic animals may be used to bioremediate environmental contaminants in vivo and serve as novel production platforms for industrial enzymes.

The methods presented in the paper expedite the screening process for Black Soldier Flies (BSF) transgenesis and further expand the toolkit for BSF synthetic biology.

Using synthetic biology, Black Soldier Flies could be developed into a novel sustainable biomanufacturing platform to valorise a broader variety of organic waste feedstocks into enhanced animal feeds, a large variety of high-value biomolecules including industrial enzymes and lipids, and improved fertiliser.

Genistein has been regarded as one important soy isoflavone with multiple health benefits, whereas its applications are limited by the low hydrophilicity. To improve the water solubility, codon optimized cyclodextrin glycosyltransferase from Paenibacillus macerans was employed for genistein transglycosylation in this study. At least four transglycosylation products were produced and identified by HPLC and LC–MS: genistein monoglucoside, diglucoside, triglucoside, and tetraglucoside derivatives. Obviously, the yields of genistein monoglucoside and genistein diglucoside exhibited great superiority compared with other two products. To maximize the yield of genistein diglucoside, various reaction conditions such as genistein dissolvents, glycosyl donors, substrates concentrations and ratios, enzyme concentrations, reaction pH, temperature, and time were optimized. Finally, the yield of genistein diglucoside was enhanced by 1.5-fold under the optimum reaction system. Our study demonstrates that the production of genistein diglucoside could be specifically enhanced, which is one important genistein derivative with better water solubility and stability.